Bayesian inference, of posterior knowledge from prior knowledge and observed evidence, is typically defined by Bayes’s rule, which says the posterior multiplied by the probability of an observation equals a joint probability. But the observation of a continuous quantity usually has probability zero, in which case Bayes’s rule says only that the unknown times zero is zero. To infer a posterior distribution from a zero-probability observation, the statistical notion of disintegration tells us to specify the observation as an expression rather than a predicate, but does not tell us how to compute the posterior. We present the first method of computing a disintegration from a probabilistic program and an expression of a quantity to be observed, even when the observation has probability zero. Because the method produces an exact posterior term and preserves a semantics in which monadic terms denote measures, it composes with other inference methods in a modular way—without sacrificing accuracy or performance.